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The Michelson Prize & Grants in Reproductive Biology is a $75M program that exists to incentivize research through prize philanthropy and grant funding to rapidly develop a permanent, single-dose, nonsurgical sterilant for male and female cats and dogs.

Listings for: "Donahoe"

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Single treatment with AAV9 Mullerian Inhibiting Substance as an ideal permanent contraceptive, Patricia Donahoe, MD - Project in progress

Project Description 

Using gene therapy expressing Mullerian Inhibiting Substance to induce sterility in mice by blocking follicle recruitment and testosterone production

PI 
Patricia Donahoe, MD, Massachusetts General Hospital, Boston, MA USA, pdonahoe@mgh.harvard.edu
Findings 
Project in progress
Publications 
Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, Pépin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A. 2017 Jan 30; Epub ahead of print.
Project Status 
Project in progress
Presentations 
Pepin D, Kano M, Sosulski A, Zhang L, Nicolaou F, Nagykery N, Wang D, Gao G, Donahoe PK. Gene therapy with Mullerian inhibiting substance as a female dog and cat contraceptive with lifetime suppression of fertility. Oral presentation. 8th International Symposium on Canine and Feline Reproduction (ISCFR), Paris, France. June 24, 2016.
Award 
$605,366 (3 years, start date 2015)