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The Michelson Prize & Grants in Reproductive Biology is a $75M program that exists to incentivize research through prize philanthropy and grant funding to rapidly develop a permanent, single-dose, nonsurgical sterilant for male and female cats and dogs.

Listings for: "Gobello"

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Prepubertal administration of GnRH agonists in domestic cats, Cristina Gobello, MV, DVM, DECAR - Project completed

Project Description 

Prevention/delay of onset of puberty in cats given a GnRH analogue in the prepubertal period.

PI 
Cristina Gobello, MV, DVM, DECAR, Faculty of Veterinary Medicine, National University of La Plata, La Plata, Argentina, cgobello@fcv.unlp.edu.ar
Findings 
1. 32 kittens (16M & 16F) were treated with 1.6 mg deslorelin acetate or a control implant within 24 hrs of birth.
2. Puberty onset was significantly delayed in treated (mean 63 wks, range 42-91 wks) versus control (mean 15.5 +/- 1.7 wks) kittens.
3. Five (2M, 3F) deslorelin treated kittens were infertile at 3 consecutive mating trials after puberty.
4. Partial (not baseline) reduction of fecal sexual hormones in first 5 weeks of life may indicate that deslorelin dose was insufficient for an irreversible effect.
5. Gonadal weight and volume were lower in treated than control males immediately after puberty and germinal epithelium and Sertoli cell numbers were diminished.
6. Gonadal weight did not differ between treated & control females, but primordial, primary & secondary follicles per mm2 were significantly decreased in treated females.
Publications 
1. Carranza A, Faya M, Fernandez P, Barbeito C, Gobello C. Histologic effect of a postnatal slow-release GnRH agonist on feline gonads. Theriogenology. 2015 May; 83(8): 1368–1372.
2. Carranza A, Faya M, Merlo ML, Batista P, Gobello C. Effect of GnRH analogs in postnatal domestic cats. Theriogenology. 2014 Jul 1; 82(1): 138-143.
Project Status 
Project completed
Presentations 
1. Carranza A, Merlo ML, Gobello C, Barbeito C. Histological effect of a GnRH agonist on the postnatal feline testis. Poster presentation. Congreso de la Sociedad Latinoamericana de Reproduccion (SOLARA), Buenos Aires, Argentina. March 25-28, 2015.
2. Carranza A, Faya M, Batista P, Fernandez P, Gobello C, Barbeito C. Histological effect of a GnRH agonist on the postnatal feline ovary: A preliminary report. Oral presentation. Il Simposio Latinoamericano de Reproduccion Animal, Universidad de Chile, Santiago, Chile. November 13-14, 2014.
3. Carranza A, de la Sota P, Diaz JD, Blanco P, Corrada Y, Gobello C. Effects of prepubertal GnRH agonist administration in domestic cats: Preliminary results. Oral presentation. 1st International Conference on Dog Population Management, York, UK. September 6, 2012.
Award 
$91,638 (3 years, start date 2011)

Prepubertal administration of a long term release GnRH agonist in domestic dogs: A Pilot Study, Cristina Gobello, MV, DVM, DECAR - Project in progress

Project Description 

Prepubertal administration of GnRH agonists in domestic dogs.

PI 
Cristina Gobello, MV, DVM, DECAR, Faculty of Veterinary Medicine, National University of La Plata, La Plata, Argentina, cgobello@fcv.unlp.edu.ar
Findings 
Project in progress
Project Status 
Project in progress
Presentations 
Faya M, Priotto M, Marchetti C, Dela Sota P, Gobello C. Neonatal administration of deslorelin acetate in domestic dogs: Preliminary results. Oral presentation. 8th International Symposium on Canine and Feline Reproduction (ISCFR), Paris, France. June 24, 2016.
Award 
$132,576 (4 years, start date 2014)