Listings for: "David Pépin"clear filter (x)
Single treatment with AAV9 anti-Müllerian hormone as an ideal permanent contraceptive , Patricia Donahoe, MD and David Pepin, PhD - Project in progress
Using gene therapy expressing anti-Müllerian hormone from an adeno-associated viral vector to induce sterility in kittens and adult cats by blocking follicle recruitment and maturation
Project in progress
- Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, Pépin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1688-E1697.
- Vansandt LM, Meinsohn MC, Godin P, Swanson WF, Pépin D et al. Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene. Nat Commun 14, 3140 (2023).
Project in progress
- Godin, P and Vansandt L. Gene delivery approach with AMH for single-dose lifetime contraception in female cats. Webinar. Botstiber Institute for Wildlife Fertility Control. September 21, 2023.
- Pépin D. Use of a gene delivery approach for single dose lifetime sterility in female cats: an alternative to spay. Oral presentation. American Society of Gene & Cell Therapy 26th Annual Meeting, Los Angeles, CA USA. May 20, 2023.
- Pépin D, Kano M, Sosulski A, Zhang L, Nicolaou F, Nagykery N, Wang D, Gao G, Donahoe PK. Gene therapy with Mullerian inhibiting substance as a female dog and cat contraceptive with lifetime suppression of fertility. Oral presentation. 8th International Symposium on Canine and Feline Reproduction (ISCFR), Paris, France. June 24, 2016.
- Pépin D, Vansandt L, Miller A, Newsom J, Kano M, Zhang L, Nagykery N, Wang D, Gao G, Donahoe PK, Swanson W. Gene therapy with AAV9 delivery of an MIS transgene inhibits estrus in female cats. Oral presentation. Alliance for Contraception in Cats & Dogs 6th International Symposium on Non-Surgical Contraceptive Methods of Pet Population Control, Boston, Massachusetts USA. July 24, 2018.
$3,075,060 (ongoing, start date 2015)