David Pepin, PhD
Assistant Professor, Surgery | Harvard Medical School, Boston, MA USA
Assistant Molecular Biologist, Surgery | Simches Research Center, Massachusetts General Hospital, Boston, MA USA
Project: Single treatment with AAV9 Mullerian Inhibiting Substance as an ideal permanent contraceptive
Show Bio »
Dr. Pépin joined the Harvard Medical School faculty in 2014 as an Instructor in the department of Surgery where he holds the title of Assistant in Surgery at the Massachusetts General Hospital, and Assistant in Molecular Biology at Harvard Medical School. Dr. Pépin was trained as a reproductive biologist at the University of Ottawa, Canada, where he completed a PhD elucidating the role of chromatin remodeling during ovarian development and in ovarian cancers. During his training, he demonstrated that epigenetic factors, and in particular chromatin regulators, orchestrate granulosa cell differentiation during folliculogenesis and control growth and differentiation of the ovarian follicle. In 2011, he joined the Pediatric Surgical Research Laboratories at the Massachusetts General Hospital as a Research Fellow and an Ann Schreiber Mentored Investigator, to lead the research team evaluating Mullerian Inhibiting Substance (MIS) for the treatment of ovarian cancer and for female contraception. He recently engineered new peptide modifications of the MIS recombinant protein and introduced them into an adeno-associated viral gene therapy vector for pre-clinical evaluation as a permanent sterilant in cats and dogs.